Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

• Conditions: Periprosthetic Bone Loss in Total Knee Replacement

• Registration Number: NCT01618149
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-06
• Study First Submitted: 2012-06-11
• Study First Submitted QC: 2012-06-12
• Last Update Submitted: 2012-06-12
• Study First Posted: 2012-06-13
• Last Update Posted: 2012-06-13
• Study Start: 2012-07
• Primary Completion: 2013-07
• Study Completion: 2013-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• severe knee osteoarthritis
• post menopausal women

Exclusion Criteria

• immune disease
• end stage of renal disease who receive dialysis
• history of fracture at ipsilateral distal femur

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
change in bone mineral density	before the surgery and after the sugery (6month ,12month)	Use dual energy x-ray absorptiometry to detect to BMD at the distal femur

Trial Locations

Locations (1)

National taiwan university hospital; 🇨🇳 Taipei, Taiwan