Cognitive rehabilitation in multiple sclerosis
- Conditions
- eurology - multiple sclerosis and cognitionNervous System DiseasesMultiple sclerosis
- Registration Number
- ISRCTN54901925
- Lead Sponsor
- Brighton and Sussex University Hospitals NHS Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
1. Diagnosis of MS by consultant neurologist to best current criteria
2. Able and willing to give informed consent
3. Cognitive impairment defined by scoring below 5th percentile on one or more of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) scales as identified at the clinic
4. Willing to commit to three 45-minute computer training sessions for six weeks
5. Home PC fulfilling experimental spec
6. Willing to attend total of 3 MRI scans at the University of Sussex MRI scanner
7. Age between 18 and 70
1. Significant change in medications in last 4 weeks
2. Relapse recovery within last 4 weeks
3. Sensorimotor dysfunction likely to interfere with PC interface
4. Significant psychiatric history/condition
5. Significant medical condition (other than MS), personal or social circumstances likely to influence cognition or study participation
6. Women who are pregnant
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Objective cognitive performance: BICAMS (Brief International Cognitive Assessment for MS), a 15-minute careening tool<br>2. Quality of life:<br>2.1. EQ-5D, a generic health-related quality of life scale<br>2.2. FAMS (Functional Assessment of MS), an MS-specific quality of life scale
- Secondary Outcome Measures
Name Time Method MRI: The data will be acquired on the 1.5T Siemens machine. The following analyses will be completed:<br>1. Voxel-based morphometry<br>2. Tensor-based morphometry<br>3. Cortical thickness<br>4. Lesion load<br>5. Resting state analysis (DMN)<br>6. DTI analysis