Dexmedetomidine on Pediatric Heart Operation
- Conditions
- Acute Renal Injury
- Interventions
- Registration Number
- NCT01920542
- Lead Sponsor
- Gachon University Gil Medical Center
- Brief Summary
we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients
- Detailed Description
dexmedetomidine, a2-adrenoreceptor agonist has been used for sedation or hemodynamic stability for operative procedure. It had been already reported that dexmedetomidine reduce the impairment of renal functon after cardiac operation in adult. we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- 1-6yr pediatric cardiac patients
- previous renal dysfunction
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description no dexmedetomidine no dexmedetomidine no administration of dexmedetomidine dexmedetomidine Dexmedetomidine administration of 0.5ug/kg dexmedetomidine for 10 min and infusion of 0.5ug/kg/h of dexmedetomidine until weaning of cardiopulmonary bypass
- Primary Outcome Measures
Name Time Method renal function from anesthetic induction up to postoperative 2h at immediate after anesthetic induction (baseline), after weaning of cardiopulmonary bypass, 2h after end of operationCPB, sodium and creatinine in the urine and serum, N-acetyl-b-glucosaminidase (NAG)and albumin in only urine could be studied
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gachon University Gil Medical Cneter
🇰🇷Incheon, Korea, Republic of