Respiratory Muscle Dysfunction in Critically Ill Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- University Medical Center Nijmegen
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Markers for inflammation
- Last Updated
- 10 years ago
Overview
Brief Summary
Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available.
The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.
Investigators
Leo Heunks
MD
University Medical Center Nijmegen
Eligibility Criteria
Inclusion Criteria
- •Severe sepsis / septic shock
- •Clinical reason for laparotomy
- •\> 18 years
Exclusion Criteria
- •No informed consent
- •Medical history of myopathy
- •Unintended weight loss before ICU admission
- •Pregnancy
- •Chronic use of corticosteroids
Outcomes
Primary Outcomes
Markers for inflammation
Time Frame: 1 day
Inflammatory mediators are measured in plasma and diaphragm at the moment the diaphragm biopsy is obtained.
Markers for activation of proteolytic pathway in the diaphragm
Time Frame: 1 day
Biochemical analysis is targeted towards activation of several proteolytic pathways (proteasome, lysosmal).
Diaphragm muscle myosin content
Time Frame: 1 day
Secondary Outcomes
- length of ICU stay(6 months)
- Length of mechanical ventilation(6 months)