Evaluating small bowel wall in Crohn's disease: a comparison of MR enterography and contrast-enhanced ultrasound

Completed

• Conditions: Crohn's disease; Inflammatory bowel disease; 10017969

• Registration Number: NL-OMON33145
• Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

- age between 18-65 years old;
- confirmed Crohn*s disease by ileocolonoscopy with biopsies;
- informed consent;

Exclusion Criteria

- cardiac failure (acute or chronic NYHA class II -IV) or other heart disease (unstable angina pectoris, recent acute coronary syndrome, severe rhythm disorders), right-to-left cardiac shunts, uncontrolled systemic hypertension, severe pulmonary hypetension and adult respiratory distress syndrome, which contraindicate the use of intravenous contrast during CE-US;
- chronic end stage kidney disease (risk for nephrogenic systemic sclerosis by use of MRI contrast agent: Gadolinium);
- patients having absolute contraindications for the MRI (intracorporal metal clips, neurostimulator, insuline pomp or pacemaker);
- patients with an acute abdomen and indication for surgery;
- pregnancy and lactation;

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The disease activity scores at CE-US (qualitative and quantitative), MRE and<br /><br>ileocolonoscopy and clinical activity score. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>