Postoperative Ileus reduction by NicOtine gum CHewing after Operatio

Completed

• Conditions: lack of peristalsis postoperative; postoperative ileus; 10017977; 10017998

• Registration Number: NL-OMON40219
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Elective colorectal surgery because of carcinoma
- >18 years of age
- Signed informed consent

Exclusion Criteria

-Severe chronic cardiovascular disease or current acute cardiovascular disease
i.e. recent myocard infarct, Prizmetal variant angina, instable angina pectoris, palpitations, recent cerebrovascular accident, intermittent claudication
- Severe liver- or kidney disease
i.e. cirrhosis, hepatitis, less than 40% of kidney function left.
- Oral or pharyngeal infection, esophagitis
- Hypersensitivity to any component of the nicotine gum
- Pregnant/ breast feeding
- Elevated risk of choking for any reason
- Unable to chew gum for any reason
- Previous colorectal surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter/ endpoint<br /><br>- Duration from surgery until first passage of feces and full tolerance of<br /><br>solid food</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters/ endpoints<br /><br>- First bowel sound, and passage of flatus after surgery<br /><br>- CRP, IL-1, IL-6, TNF-a, white bloodcell ( WBC) level<br /><br>- Postoperative opioid consumption<br /><br>- Patient hospitalization length<br /><br>- Cardiovascular complications</p><br>