Effect of dexamethasone nebulization on attenuation of sore throat, hoarseness of voice and cough in general anaesthesia.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/07/035146
• Lead Sponsor: JLN Medical College Ajmer

Brief Summary

Sore throat, hoarseness of voice and cough are common postoperative complications following endotracheal intubation, and are more commonly found in the pediatric population. These problems, although self limiting, lead to patient’s discomfort.

Postoperative sore throat along with hoarseness of voice and cough contributes to postoperative morbidity and patient dissatisfaction. Post-operative sore throat has been rated by patients as the eighth most adverse effect in the postoperative period.



Dexamethasone is a corticosteroid which has been used here owing to its anti-inflammatory and membrane-stabilizing action. Its onset for action is 1 hour after administration. It is used in the treatment of many inflammatory and auto-immune diseases such as rheumatoid arthritis, severe allergies, asthma, chronic obstructive lung disease and ocular pains due to ophthalmic surgeries.

It has been used for nebulization for attenuation of postoperative sore throat due to its anti inflammatory action.



It will be used in our study in the dose of 0.16 mg/kg with the total volume made up to 5ml using saline for prevention of postoperative sore throat.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-07-26
• Study Start: 2021-08-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients between 6-14 years of either sex Undergoing surgeries under general anaesthesia in supine position Duration of surgery up to 2 hours ASA physical status – I,II.

Exclusion Criteria

• Age < 6and >14 years ASA physical status III and above Mallampati grade > 2 Any psychiatric disorder or history of epilepsy Neurosurgical patients with raised intracranial pressure Patients with cardiac anomalies Patients sensitive or allergic to study drug History of pre-operative sore throat, oral surgeries, asthma, chronic obstructive pulmonary disease, head and neck surgeries.
• Recent non-steroidal drug medication Anticipated difficult intubation Patient and/or his/her legally acceptable representative not willing to provide their voluntary written informed consent for participation in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the incidence and severity of-	0hr,2hr,4hr,6hr,12hr,24hr
Postoperative sore throat (POST)	0hr,2hr,4hr,6hr,12hr,24hr
Postoperative Hoarseness of voice	0hr,2hr,4hr,6hr,12hr,24hr
Post-operative Cough	0hr,2hr,4hr,6hr,12hr,24hr

Secondary Outcome Measures

Name	Time	Method
Haemodynamic parameters (HR, SBP, DBP, MAP & SpO2)	Side effects, if any

Trial Locations

Locations (1)

JLN Medical College Ajmer; 🇮🇳 Ajmer, RAJASTHAN, India

JLN Medical College Ajmer

🇮🇳Ajmer, RAJASTHAN, India

Dr Kavita Jain

Principal investigator

9414006151

drkavitajain15@gmail.com