The Development of Allergic Rhinitis in Children Previously Diagnosed as Nonallergic Rhinitis

Completed

• Conditions: Allergic Rhinitis (Disorder)
• Interventions: Procedure: skin prick test

• Registration Number: NCT01068808
• Lead Sponsor: Mahidol University

Brief Summary

The purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

Detailed Description

Rhinitis is a common condition associated with significant effects on quality of life. Rhinitis may be divided into two groups, those with concurrent allergy (allergic rhinitis, AR) and those without allergy but who still suffer from nasal symptoms (nonallergic rhinitis, NAR).

Evidence indicated that adult with NAR can have de novo sensitization to aeroallergen (24%), suggesting that patients with NAR might evolve to AR. Thus the purpose of this study is to evaluate development of allergic rhinitis in children with nonallergic rhinitis.

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2010-02-12
• Study First Submitted QC: 2010-02-12
• Study First Posted: 2010-02-15
• Primary Completion: 2012-06
• Study Completion: 2012-08
• Status Verified: 2013-02
• Last Update Submitted: 2013-02-18
• Last Update Posted: 2013-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 175

Inclusion Criteria

• Children between the age of 1 year and 15 years with the diagnosis of nonallergic rhinitis who are attending the pediatric allergy clinic during Jan 2005 - Dec 2007.

Exclusion Criteria

• Patients who have allergic rhinitis and underlying disease eg.chronic renal disease, liver disease, heart disease, cancer.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Nonallergic rhinitis	skin prick test	Nonallergic rhinitis (negative skin prick test)

Primary Outcome Measures

Name	Time	Method
To evaluate the development of AR in children who were previously diagnosed with NAR	24 months

Secondary Outcome Measures

Name	Time	Method
To determine the persistence and severity of the symptoms, new comorbidities and triggering factors in children with nonallergic rhinitis	24 months

Trial Locations

Locations (1)

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University; 🇹🇭 Bangkok, Thailand