Clinical and Molecular Aspects of Early Osteoarthritis

Completed

• Conditions: Early Osteoarthritis

• Registration Number: NCT04267510
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis. To our knowledge, there are no large-scale genetic studies on people with early osteoarthritis. The investigators therefore sought to study the causes of monogenic osteoarthritis in people suffering from early non-syndromic osteoarthritis.

Material and method From 2013 to 2019, experts in constitutional bone disease sent patients with non-syndromic early osteoarthritis for genetic analysis to our center of competence for constitutional bone diseases. The sequencing of a panel of genes was carried out by NGS.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01-01
• Primary Completion: 2019-12-01
• Study Completion: 2020-01-01
• Status Verified: 2020-02
• Study First Submitted: 2020-02-07
• Study First Submitted QC: 2020-02-11
• Last Update Submitted: 2020-02-11
• Study First Posted: 2020-02-13
• Last Update Posted: 2020-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients with early osteoarthritis who have undergone genetic sequencing

Exclusion Criteria

• Patients refusing to participate in research

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
identification of genetic mutation	1 day	sequencing out by NGS
number of genetic mutation	1 day	sequencing out by NGS

Trial Locations

Locations (1)

UH Montpellier; 🇫🇷 Montpellier, France