Effect of Vitamin D Supplementation on Cardiovascular and Respiratory Disease Event Rates, and the incidence of fractures

Phase 3

Completed

• Conditions: Cardiovascular Disease; Respiratory Disease; Non-vertebral fractures; Cancer; Cardiovascular - Coronary heart disease; Respiratory - Chronic obstructive pulmonary disease; Injuries and Accidents - Fractures; Cancer - Any cancer

• Registration Number: ACTRN12611000402943
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5110

Inclusion Criteria

1.age 50-84 years;
2.ability to give informed consent;
3.resident in Auckland at recruitment;
4.anticipated residence in New Zealand for the 4-year study period.

Exclusion Criteria

1.current use of vitamin D supplements (>600 IU per day if aged 50-70 years; >800 IU per day if aged 71-84 years);
2.diagnosis of psychiatric disorders that would limit ability to comply with study protocol - ie. history of regular exacerbation of major psychosis (schizophrenia, bipolar disorder) in last 2 years
3.history of hypercalcaemia, nephrolithiasis, sarcoidosis, parathyroid disease or gastric bypass surgery;
4.enrolled in another study which could affect participation in the vitamin D study;
5.serum calcium from baseline blood sample >2.50 mmol/L.

Study & Design

• Study Type: Interventional
• Study Design: Not specified