Does hypothyroidism induced by thyroid hormone withdrawal lead to permanent modificationsof the DNA?
Recruiting
- Conditions
- Patients with differentiated thyroid cancer
- Registration Number
- NL-OMON20919
- Lead Sponsor
- Erasmus MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Have the capacity to understand and willingness to sign an informed consent form
2. Planned for total thyroidectomy because of differentiated thyroid cancer
3. Aged 18-80 years
Exclusion Criteria
1. Alcohol abuse
2. Other malignancy
3. Clinically relevant active systemic disease (such as autoimmune or infectious diseases)
4. Pregnancy
5. Use drugs interfering with thyroid hormone metabolism (e.g. antiepileptic drugs, amiodarone,
and lithium)
6. Other primary thyroid disease
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Epigenetic DNA modifications
- Secondary Outcome Measures
Name Time Method