Evaluation of Surgical Stress Index (SSI) During Sevoflurane/Remifentanil Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- SSI, compared to standard monitoring variables
研究概览
简要总结
The aim of the present prospective randomized study was to challenge the ability of SSI to detect painful stimulation during sevoflurane - remifentanil anesthesia.
详细描述
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Whereas monitoring of depth of hypnosis, and muscle relaxation can be regarded as accepted, determination of the nociception is based on clinical signs like somatic or autonomic responses.
Recently, the multivariate surgical stress index (SSI)has been demonstrated to correlate with surgical stress intensity. Thus, SSI might be a useful variable to adjust analgesic drug administration in individual patients.
We want to investigate whether SSI is able to indicate nociception following standardized noxious stimulation during balanced sevoflurane - remifentanil anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Diagnostic
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •age between 18 and 65 years
- •ASA physical status 1-2
- •elective surgery in general anesthesia of 1 to 2 hours
- •written informed consent
排除标准
- •pregnancy
- •history of cardiac arrhythmia
- •presence of any neuromuscular or neurological disease
- •use of CNS-active medication or abuse of alcohol or illicit drugs
结局指标
主要结局
SSI, compared to standard monitoring variables
时间窗: during anesthesia
次要结局
未报告次要终点
研究者
Berthold Bein
Prof. Dr. med.
University Hospital Schleswig-Holstein