TCTR20220423002已完成4 期
Effectiveness of 0.3% Hyaluronic Acid Eye Drops in the Treatment of Benign Essential Blepharospasm and Hemifacial Spasm
Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.0 个研究点目标入组 47 人开始时间: 2022年4月23日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 47
研究概览
简要总结
After 3 months of treatment with 0.3% HA eye drops, patients with BEB and HSF experienced significant improvements in spasm score (p 0.030, p 0.013), TBUT (p 0.001, p 0.010), and mean corneal fluorescein staining grade (p 0.005, p 0.020). They also reported a significant improvement in the mean subjective dry eye symptom questionnaire score (p 0.010, p 0.007). All parameters in no intervention arm were not significantly changed.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •All patients with the diagnosis of BEB or HFS who were concurrently treated with BoNT-A injections, regardless of dry eye symptoms, and willing to enroll in the study.
排除标准
- •1. neurological abnormalities other than craniocervical dystonia
- •2. features suggestive of secondary dystonias
- •3. history of other active ocular surface disorders or anterior segment diseases
- •4. ocular trauma or eyelid/ocular surgery in the preceding 6 months
- •5. contact lens wear
- •6. concurrent application of any type(s) of artificial tears or other treatments for DED in the preceding 3 months.
研究者
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