Protein S100B Versus Neutrophils/Lymphocytes Ratio in Early Prediction of Brain Injury
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Tanta University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Protein S100B
Study Overview
Brief Summary
The study aimed to evaluate the role of Protein S100B versus the neutrophil-to-lymphocyte ratio (NLR) as an early predictor biomarker and the value of amplitude-integrated electroencephalography (aEEG) as an early predictor and prognostic method for neonatal brain injury susceptibility and severity.
Detailed Description
The most prevalent types of newborn brain injury (NBI) are intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL), and hypoxic-ischemic encephalopathy (HIE), which can affect neonates born at any gestational age (GA).
Amplitude-integrated EEG (aEEG) is another early predictor and prognostic technique for Neonatal Brain Injury. Electrophysiological brain activity, as measured by aEEG, is a well-established method for giving information on the functional and metabolic status of the brain and the incidence of epileptic seizure episodes.
S100B belongs to the S100 family. Because it is soluble in a 100% saturated solution of ammonium sulfate, it was designated "S100." S100 protein is a calcium-binding cytosolic protein with a molecular weight of 21 kDa comprised of 2 monomers, which are found in a variety of cells and are primarily concentrated in the glial cells of the CNS. Due to its molecular weight, peripheral blood will detect only S100B.
The neutrophil-to-lymphocyte ratio (NLR) reflects changes in neutrophil and lymphocyte levels, which is an indication of inflammation.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 28 Weeks to 36 Weeks (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Gestational age between 28 and 36 weeks.
- •Prematurity.
Exclusion Criteria
- •Intrauterine growth restriction (IUGR).
- •Multiple congenital anomalies.
- •Chromosomal abnormalities.
- •Preterm less than 28 weeks.
- •Infant of diabetic mother.
Outcomes
Primary Outcomes
Protein S100B
Time Frame: Third day of seizure activity
Serum level of S100B Protein was measured on the first and third days of seizure activity by ELISA.
Secondary Outcomes
- Neutrophils/Lymphocytes Ratio(Third day of seizure activity)
Investigators
Asmaa Mahmoud Abdel Hamid Elmesiry
Lecturer of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University