Protein S100B Versus Neutrophils/Lymphocytes Ratio in Early Prediction of Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Protein S100B
研究概览
简要总结
The study aimed to evaluate the role of Protein S100B versus the neutrophil-to-lymphocyte ratio (NLR) as an early predictor biomarker and the value of amplitude-integrated electroencephalography (aEEG) as an early predictor and prognostic method for neonatal brain injury susceptibility and severity.
详细描述
The most prevalent types of newborn brain injury (NBI) are intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL), and hypoxic-ischemic encephalopathy (HIE), which can affect neonates born at any gestational age (GA).
Amplitude-integrated EEG (aEEG) is another early predictor and prognostic technique for Neonatal Brain Injury. Electrophysiological brain activity, as measured by aEEG, is a well-established method for giving information on the functional and metabolic status of the brain and the incidence of epileptic seizure episodes.
S100B belongs to the S100 family. Because it is soluble in a 100% saturated solution of ammonium sulfate, it was designated "S100." S100 protein is a calcium-binding cytosolic protein with a molecular weight of 21 kDa comprised of 2 monomers, which are found in a variety of cells and are primarily concentrated in the glial cells of the CNS. Due to its molecular weight, peripheral blood will detect only S100B.
The neutrophil-to-lymphocyte ratio (NLR) reflects changes in neutrophil and lymphocyte levels, which is an indication of inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 28 Weeks 至 36 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gestational age between 28 and 36 weeks.
- •Prematurity.
排除标准
- •Intrauterine growth restriction (IUGR).
- •Multiple congenital anomalies.
- •Chromosomal abnormalities.
- •Preterm less than 28 weeks.
- •Infant of diabetic mother.
结局指标
主要结局
Protein S100B
时间窗: Third day of seizure activity
Serum level of S100B Protein was measured on the first and third days of seizure activity by ELISA.
次要结局
- Neutrophils/Lymphocytes Ratio(Third day of seizure activity)
研究者
Asmaa Mahmoud Abdel Hamid Elmesiry
Lecturer of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University