Age and Gender Differences in Multiple Sclerosis Pathology
- Conditions
- G35.0
- Registration Number
- DRKS00016543
- Lead Sponsor
- niversitätsmedizin Göttingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Patients with brain biopsies taken for diagnostic reasons with 1) pediatric MS patients, or 2) patients with late onset MS (= 50 years) or 3) control patients (disease onset at the age of 20-40 years).
Exclusion Criteria
MRI studies: 1) Female subjects who are currently pregnant 2) Known history of sensitivity to gadopentate or mannitol 3) Metallic device which is known to interfere with magnet 4) Known history of claustrophobia
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint are histopathological characteristics that will be determined in pathological samples (after performing histological/immunohistochemical stainings the number of inflammatory cells, the axons, acutely damaged axons and oligodendrocytes will be quantified using the microscope). A semiquantitative analysis of the remyelination will be performed. Results of the different groups will be compared with statistical methods.
- Secondary Outcome Measures
Name Time Method Secondary end point: Histopathological results will be correlated with clinical (relapse rate, disease course, EDSS) and MRI parameters (T2 lesion load, T1 hypointense lesions, Gd-enhancing lesions).<br>