Inspiratory muscle training in intensive care unit patients.

Not Applicable

Recruiting

• Conditions: Acute Respiratory Distress Sindromy; sepsis; pneumonia; critical illness polyneuropathy; respiratory insufficiency; intensive care unit; weaning of mechanical ventilation.; C08.618.846; E02.041.625.950; E02.760.190.400

• Registration Number: RBR-32vkkr
• Lead Sponsor: Faculdade de Ciências Médicas da Universidade Estadual de Campinas

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-08-27
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adequate gas exchange as indicated by a PaO2 above 60 mmHg while breathing with an FIO2 of 0.50 or less; hemodynamically stable for 24 hours prior to participation or requiring only minimal intravenous pressor agents (dobutamine or dopamine less than 5mcg/kg/min, phenylephrine less than 1 mcg/kg/min); be able to follow simple verbal directions related to inspiratory muscle strength testing and training; receiving assist control or SIMV (synchronized intermittent mandatory ventilation) or pressure support ventilation via a tracheostomy, pressure support ventilation less than 15 cmH2O and PEEP (positive end expiratory pressure) less than 10 cmH2O. Unable to sustain unsupported breathing for at least 24 consecutive hours following resolution of factor(s) precipitating respiratory failure.

Exclusion Criteria

Inadequate gas exchange as indicated by a PaO2 under 60 mmHg while breathing with 0.50 or less percentage of oxigen; be medically instable and unready to be weaned from the ventilator as determined by the attending physician; hemodynamically instable for 24 hours requiring intravenous pressor agents (dobutamine or dopamine upper than 5mcg/kg/min, phenyleprine upper than 1mcg/kg/min); receiving continuous sedation and mechanical ventilation; have any progressive neuromuscular disease such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis, or other neuromuscular disorder that would interfere with responding to inspiratory muscle training; have an anticipated life expectancy under 12 months; have a core temperature above 38.5°C; have a spinal cord injury above T8 and any skeletal pathology (scoliosis, flail chest, spinal instrumentation) that would seriously impair the movement of the chest wall and ribs; using any type of home mechanical ventilation support prior to hospitalization; body mass index upper than 40 kg/m2; require continuous sedative or analgesic agents that will depress respiratory drive or the ability to follow commands; excessive secretions (requiring suctioning more than once every hour).

Study & Design

• Study Type: Intervention
• Study Design: Not specified