NCT02869282撤回不适用
Study Of The Expression Of Circulating And Intra-Tumoral Chemokines In Patients With Prostate Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 145
- 试验地点
- 1
- 主要终点
- Concentration of chemokines initially detectable in the blood or urine and evolution during follow-up: CXCL1, CXCL5, CXCL8, CXCL12, cytokine IL-6. Measurement was made by Luminex or elisa technical
研究概览
简要总结
Multicentric, observational, prospective, non-interventional study with occasional biological sample collection (serum bank, urine bank and tumor bank)
详细描述
This project is an exploratory study, based on the hypothesis of involvement of chemokines in hormonal escape of prostate cancers.
The two main objectives are:
- To describe the variations in expression of chemokines in serum and urine level in patients with prostate cancer
- And to study the disease stage and intra-prostatic concentrations of chemokines based on serum and urine concentrations of chemokines before treatment initiation.
These estimates can be used in future trials set up for the management of prostate cancer
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients with a localized or metastatic prostate adenocarcinoma for which a new treatment will be implemented (hormone therapy for single biological relapse or relapses and metastatic hormone-sensitive) or chemotherapy (for biological relapses and / or metastatic hormone-resistant)
- •Patients with a detectable PSA (Prostate-Specific Antigen)
- •Patients who signed an informed consent
- •Patients over 18 years
- •Patients belonging to the social security scheme
排除标准
- •Active Hepatitis B or C virus
- •HIV positive
- •Patients who have received prior chemotherapy
- •Patients with a second neoplasia treated in the last 5 years
结局指标
主要结局
Concentration of chemokines initially detectable in the blood or urine and evolution during follow-up: CXCL1, CXCL5, CXCL8, CXCL12, cytokine IL-6. Measurement was made by Luminex or elisa technical
时间窗: At 6 months
次要结局
未报告次要终点
研究者
研究点 (1)
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