NCT00005853已完成2 期
Therapy of Myelodysplastic Syndrome (MDS) With Antithymocyte Globulin (ATG) and TNFR:Fc
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining different types of biological therapies may kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of biological therapy in treating patients who have myelodysplastic syndrome.
详细描述
OBJECTIVES:
- Determine the frequency of hematologic responses in patients with myelodysplastic syndrome treated with anti-thymocyte globulin and tumor necrosis factor receptor IgG chimera.
- Correlate phenotypic, cytogenetic, and functional disease characteristics with treatment responses in these patients.
- Determine the safety of this treatment regimen in this patient population.
OUTLINE: Patients receive anti-thymocyte globulin IV over 8 hours daily for 4 days followed by tumor necrosis factor receptor IgG chimera subcutaneously twice weekly for 16 weeks.
Patients are followed at 8, 16, and 20 weeks.
PROJECTED ACCRUAL: A total of 15 patients will be accrued for this study.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究者
研究点 (2)
Loading locations...
相似试验
已完成
1 期
Arsenic Trioxide and Etanercept in Treating Patients With Myelodysplastic SyndromesMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative DiseasesLeukemiaNCT00093366Fred Hutchinson Cancer Center32
已完成
2 期
Anti-Thymocyte Globulin and Etanercept in Treating Patients With Myelodysplastic SyndromesMyelodysplastic SyndromesMyelodysplastic/Myeloproliferative DiseasesLeukemiaNCT00217386Fred Hutchinson Cancer Center30
已完成
1 期
Vaccine Therapy in Treating Patients With Myelodysplastic SyndromeMyelodysplastic SyndromesLeukemiaNCT00003959Memorial Sloan Kettering Cancer Center1
招募中
1 期
Advancing treatment therapies in MyelodysplasiaMyelodysplasiaCancer - Leukaemia - Acute leukaemiaACTRN12622000410752Australasian Leukaemia and Lymphoma Group (ALLG)1,000
Unknown
2 期
Combination Chemotherapy in Treating Patients With Myelodysplastic SyndromeMyelodysplastic SyndromesLeukemiaNCT00003827ALZA25