跳至主要内容
临床试验/NCT07084727
NCT07084727招募中不适用

Retinal Biomarkers as a Tool for Early Detection of Endothelial Dysfunction in Women With Preeclampsia

University Hospital, Antwerp1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年7月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
60
试验地点
1
主要终点
Retinal biomarkers

研究概览

简要总结

Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Health Services Research
盲法
None

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Female
接受健康志愿者
是

入选标准

  • •at least 18 years old
  • •willing to undergo vascular assessments
  • •informed consent signed

排除标准

  • •Unwilling to provide informed consent
  • •Open-angle glaucoma
  • •Epilepsia
  • •(gestational) Diabetes
  • •Multiple pregnancies
  • •Fetal malformations
  • •Hypercholesterolemia
  • •Kidney disease
  • •Auto-immune disorders
  • •Connective tissue diseases

研究组 & 干预措施

Interventional group

Other

All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.

干预措施: Arterial stiffness (Other)

Interventional group

Other

All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.

干预措施: Flow-meditad dilatation (Other)

Interventional group

Other

All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.

干预措施: Dynamic retinal vessel analyzer (Other)

结局指标

主要结局

Retinal biomarkers

时间窗: Baseline

Early (retinal) biomarkers for cardiovascular risk in patients with preeclampsia, assessed by DVA.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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