Retinal Biomarkers as a Tool for Early Detection of Endothelial Dysfunction in Women With Preeclampsia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Retinal biomarkers
研究概览
简要总结
Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •at least 18 years old
- •willing to undergo vascular assessments
- •informed consent signed
排除标准
- •Unwilling to provide informed consent
- •Open-angle glaucoma
- •Epilepsia
- •(gestational) Diabetes
- •Multiple pregnancies
- •Fetal malformations
- •Hypercholesterolemia
- •Kidney disease
- •Auto-immune disorders
- •Connective tissue diseases
研究组 & 干预措施
Interventional group
All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.
干预措施: Arterial stiffness (Other)
Interventional group
All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.
干预措施: Flow-meditad dilatation (Other)
Interventional group
All patients in this study will undergo all vascular assessments including pulse wave velocity, pulse wave analysis, flow-mediated dilation, fundus photography and dynamic retinal vessel analysis.
干预措施: Dynamic retinal vessel analyzer (Other)
结局指标
主要结局
Retinal biomarkers
时间窗: Baseline
Early (retinal) biomarkers for cardiovascular risk in patients with preeclampsia, assessed by DVA.
次要结局
未报告次要终点
