Volatile Versus Propofol Anesthesia in OPCAB
- Registration Number
- NCT02222142
- Lead Sponsor
- Samsung Medical Center
- Brief Summary
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.
- Detailed Description
Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1080
- OPCAB
- On pump conversion
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Isoflurane group Isoflurane Isoflurane inhalational anesthesia during OPCAB
- Primary Outcome Measures
Name Time Method CK-MB, CRP Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2 Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2
- Secondary Outcome Measures
Name Time Method Clinical adverse outcomes until 1 year after OPCAB clinical adverse outcomes until postoperative 1 year
Trial Locations
- Locations (1)
Samsung medical center
🇰🇷Seoul, Korea, Republic of