Propofol and Isoflurane effects in thoracic surgeries
- Conditions
- Anasthesia.Anaesthetic, unspecified
- Registration Number
- IRCT2013122615942N1
- Lead Sponsor
- Vice Chancellor for Research of Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
The major inclusion criteria:
The age range of 18-75 years old; ASA class I (Healthy person) and III (Severe systemic disease); The consent to undergo thoracic surgery with OLV, according to the study conditions
The major exclusion criteria:
Liver malfunction (Aspartate transaminase (AST) more than 40, Alanine transaminase (ALT) more than 40); Ischemic or valvular heart disease (history of cardiovascular diseases, physical status, Electrocardiogram (EKG) and echocardiography of the patients were analyzed); Recent use of anesthetic medications; Obstructive and end-stage restrictive pulmonary disease; Patients with one-lung ventilationin (OLV) less than 30 min; Patients with End -Tidal CO2 (ETCO2) more than 45 mmHg, and the respiratory rate of 12 breaths per minute; Patients who have pathological problems in the left lung (pulmonary), according to High Resolution Computed Tomography (HRCT) and pulmonary function tests (PFT) before the surgery.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean pressure of arterial oxygen. Timepoint: During two lung ventilation and in 5, 10 and 20 minute after one lung ventilation. Method of measurement: ABG Test by GEM premier 3000.;Mean Arterial pressure. Timepoint: During two lung ventilation and in 5, 10 and 20 minute after one lung ventilation. Method of measurement: ABG Test by GEM premier 3000.;Heart Rate. Timepoint: During two lung ventilation and in 5, 10 and 20 minute after one lung ventilation. Method of measurement: ABG Test by GEM premier 3000.
- Secondary Outcome Measures
Name Time Method Arterial oxygen saturation. Timepoint: During ventilation of two lungs, 5, 10 and 20 minute after one lung ventilation. Method of measurement: Monitoring.