Comparison of two commonly used anaesthetic agents on the blood vessels in the brain of patients with brain bleed from thinned out blood vessels
Phase 2
Completed
- Conditions
- Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery
- Registration Number
- CTRI/2019/04/018637
- Lead Sponsor
- Dept of Anaesthesia and Intensive CarePGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1.Patients with ruptured cerebral aneurysm scheduled for coil embolisation procedure
2.Age 18 years and above
3.WFNS grade 1and 2 patients36 /Modified Hunt and Hess Clinical Grade 1 and 2 patients
4.Modified Fisher grade 1 and 2 patients
Exclusion Criteria
1.Hemodynamically unstable patients
2Intubated patients
3.Patients receiving sedative agents
4.Patients diagnosed to have vasculitis
5.Patients diagnosed to have cerebral vasospasm clinically or radiologically
6.Hematocrit of less than 30% and more than 45%
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effects of propofol (TIVA) and sevoflurane (VIMA) on the luminal diameter of cerebral vessels in patients undergoing endovascular embolisation for ruptured cerebral aneurysm.Timepoint: 1.Just prior to anaesthetic exposure <br/ ><br>2.60 minutes after induction of anaesthesia. <br/ ><br>3.Just after the coiling procedure <br/ ><br>
- Secondary Outcome Measures
Name Time Method 2)To compare the changes on cerebral blood flow with propofol and sevoflurane by measuring cerebral transit time in patients undergoing endovascular embolisation for ruptured cerebral aneurysm.Timepoint: 1.Just prior to anaesthetic exposure <br/ ><br>2.60 minutes after induction of anaesthesia. <br/ ><br>3.Just after the coiling procedure