Assessment of the effects of anaesthetic agents on cerebral vasculature.
Phase 4
- Conditions
- Health Condition 1: I679- Cerebrovascular disease, unspecified
- Registration Number
- CTRI/2022/02/040527
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients aged 18years to 75 years
Patients scheduled for therapeutic endovascular neuro-interventions
1. Patients with ruptured aneurysm undergoing endovascular coiling/ Flow diversion
2. Patients with unruptured aneurysm undergoing endovascular interventions
3. Patients with intracranial AVM undergoing endovascular embolisation
Exclusion Criteria
1.Hemodynamically unstable patients
2.Intubated Patients
3.Patients having derranged Renal Parameters
4.Patients diagnosed to be having vasculitis
5.Patients diagnosed to be having cerebral vasospasm in preprocedural angiography
6.Patients diagnosed to be having hydrocephalus
7.Patients having abnormal coagulation parameters
8.Patients having Hemoglobin < 10gm/dl or Hematocrit < 30%
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effects directly on the luminal diameter of cerebral vessels on the diseased <br/ ><br>side between propofol and sevofluraneTimepoint: 1. Pre-Induction of anaesthesia <br/ ><br>2. 1 hour post-induction of anaesthesia <br/ ><br>3. Post Completion of the Neuro-Endovascular Procedure
- Secondary Outcome Measures
Name Time Method 1. To compare the changes on cerebral blood flow indirectly by measuring cerebral transit <br/ ><br>time (CTT) between propofol and sevoflurane anaesthesia <br/ ><br>2.To compare the effect on pro-inflammatory biomarker Neuron Specific Enolase (NSE) <br/ ><br>between propofol and sevoflurane anaesthesia <br/ ><br>Timepoint: 1.Pre-Induction of anaesthesia <br/ ><br>2. 1 hour post-induction of anaesthesia <br/ ><br>3. Post completion of neuroendovascular procedure <br/ ><br>4. NSE estimation prior to procedure and 24 hours post procedure