A Pharmacotherapeutical study of two source plants of Shalparni Desmodium gangeticum DC and Desmodium laxiflorum DC in Vatarakta
试验速览
- 阶段
- 1/2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- change in clinical symptoms of Vatarakta gout
研究概览
简要总结
Shalaparniis one of the contents of Dashamoola, a widely used combination in Ayurveda. Acharya Charaka hasdelineated, Shalaparni as a single drug in the management of Vatarakta.So, keeping this in view, present study was carried out to evaluate comparativetherapeutic effect of Desmodium gangeticum and Desmodium laxiflorumin purvarupa and rupa of Vatarakta
Total 66 patientswere registered in the clinical study. 30 patients in group-A and 31 patientsin group-B were completed in the study. After completion of the study and statisticalanalysis unveiling of the blinding was done.
In comparative effect Group B (D.gangeticum) produced betterresults in Sandhishoola Ruk bhutva-Bhutva Nistoda and Sadanamwhereas better result in Daha and Sphuran-ayama were observed in GroupA**.** In bio-chemical parametersGroup B (D.gangeticum) was better in S. cholesterol, S. HDL Uricacid and CRP whereas Group A (D.laxiflorum) produced better result on S.Triglycerides.
In Group A (D.laxiflorum)out of 30 completed patients, 80% were mildly improved and 20% were moderatelyimproved at the end of treatment period. In Group B (D.gangeticum) outof 31 completed patients 9.67% were unchanged, 64.51% were mildly improved and25.80% of patients showed moderately improvement at the end of treatmentperiod.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 16.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients presenting with the classical signs and symptoms of purvarupa early symptoms and rupa symptoms of Vatarakta gout Patients having classical signs and symptoms with less than 1year chronicity.
排除标准
- •â€¢Patients below 16 and above 70 years of age.
- •Patients having chronicity more than 1year and of Gambhir Vatarakta deep seated gout Patients suffering from any systemic diseases like Diabetes Hypertension Cardiac anomaly Chronic renal failure Liver cirrhosis Pregnant or lactating mother.
结局指标
主要结局
change in clinical symptoms of Vatarakta gout
时间窗: 4 weeks study and 2 weeks follow up
Episodes of joints Pain
时间窗: 4 weeks study and 2 weeks follow up
Burning sensation in joints
时间窗: 4 weeks study and 2 weeks follow up
Parasthesia of joints
时间窗: 4 weeks study and 2 weeks follow up
Discolouration on Joints
时间窗: 4 weeks study and 2 weeks follow up
Fatigue
时间窗: 4 weeks study and 2 weeks follow up
次要结局
- changes in Biochemical heamatological parameters(4 weeks study and 2 weeks follow up)