NCT03014882Unknown1 期
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?
适应症
干预措施
试验速览
- 阶段
- 1 期
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- DNA fragmentation index
研究概览
简要总结
Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.
We aimed at investigating the current DNA damage in the sperms of adult patients with beta thalassemia major and the effect generated by giving antioxidant treatment for 6 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Pubertal patients with beta thalassemia major
排除标准
- •Associated endcrinopathy
研究组 & 干预措施
Antioxidant treatment
Other
干预措施: L-Carnitine and N-acetyl cysteine (Drug)
结局指标
主要结局
DNA fragmentation index
时间窗: 6 months
次要结局
未报告次要终点
研究者
Alaa Youssef Ahmed
Dr
Ain Shams University
研究点 (2)
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