Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among human immunodeficiency virus (HIV)-infected patients: the AIMS study
Not Applicable
Completed
- Conditions
- Human immunodeficiency virus (HIV)Infections and Infestations
- Registration Number
- ISRCTN97730834
- Lead Sponsor
- Academic Medical Centre (AMC) (Netherlands)
- Brief Summary
2005 Results article in https://www.ncbi.nlm.nih.gov/pubmed/15989434 results of pilot study results 2010 Results article in https://pubmed.ncbi.nlm.nih.gov/20658830/ results (added 22/10/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 133
Inclusion Criteria
1. HIV-1 positive, using highly active anti-retroviral therapy (HAART)
2. Treatment experience for at least 6 months, with a maximum of 5 years
3. Sufficient knowledge of the English or Dutch language (verbal and in writing)
4. No current psychiatric, drug or alcohol problems
5. More or less stable housing
6. Able to give informed consent.
Exclusion Criteria
Does not comply with the above inclusion criteria
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. The primary purpose of the proposed study is to investigate whether or not adherence to HAART can be significantly increased by HIV-nurses using the AIM-Strategy, and whether this is sustained over time<br> 2. Whether or not these improvements result in a decrease of plasma and intracellular HIV-RNA<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Furthermore, a questionnaire will be used to see which cognitive variables of the patients are related to (non) adherence and to evaluate whether or not the intervention successfully changes those cognitive variables that cause non-adherence<br> 2. Finally, a process evaluation will be conducted among patients, HIV-nurses and physicians to investigate the advantages (e.g., insight in adherence, detection of treatment problems, improved communication) and disadvantages (e.g. duration intervention sessions, user-friendliness of equipment) of the use of AIMS versus providing standard care<br>