跳至主要内容
临床试验/NCT02315261
NCT02315261已完成不适用

Effectiveness of Epidural Anesthesia for Thoracic and Abdominal Surgery in Siriraj Hospital

Siriraj Hospital1 个研究点 分布在 1 个国家目标入组 364 人开始时间: 2014年12月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
364
试验地点
1
主要终点
Number of Patients Reporting Postoperative Verbal Rating Scale Pain at Rest More Than 7

研究概览

简要总结

This study aims to evaluate the effectiveness of the epidural analgesia in patients having elective thoracic and abdominal surgery under general anesthesia combined with epidural analgesia in Siriraj Hospital.

详细描述

Epidural analgesia is the recommended perioperative analgesia in patients having major surgery in order to significantly reduced pain scores, minimize patient distress and can accelerate postoperative recovery especially with the major operation This technique has been reported to provide better pain control and less postoperative fatigue compared with patients receiving general anesthesia alone.Additionally, it is recommended in patients having major surgery to allow patients to mobilize quickly and have effective mobilization.This technique has been shown to be highly efficient at preventing postoperative ileus and various complications. Moreover, epidural analgesic technique is demonstrated to be safer and have fewer side effects than using intravenous opioids alone.

However, the epidural technique is not universally successful and the number of patients experiencing inadequate analgesia with this technique is approximately 12-32%. The failure of epidural analgesia is still a frequent clinical problem and needs active management including a new block or other analgesic medication in order to rescue postoperative pain. Previous study showed that the incidence of patients having epidural analgesia with postoperative moderate pain was 20.9% and that with severe pain was 7.8%. In Siriraj Hospital, recent study showed that 19.6% of patients having elective upper abdominal surgery under general anesthesia combined with epidural analgesia reported severe first pain scores in post anesthetic care unit.27 As a result of severe pain, patients needed a number of intervention and management from acute pain service, and finally spent longer time in post anesthetic care unit.

Inadequate pain control in patients receiving epidural analgesia frequently occurred in clinical practice but the number of the success rate or the failure rate have not been reported in our hospital. This study aims to evaluate the effectiveness of the epidural analgesia in patients having elective thoracic and abdominal surgery under general anesthesia combined with epidural analgesia in Siriraj Hospital.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients aged more than 18 years old scheduled to have thoracic or abdominal surgery under general anesthesia combined with epidural analgesia in Siriraj hospital

排除标准

  • inability to communicate or inform pain score
  • cesarean section or labor analgesia
  • additional analgesic techniques (spinal analgesia, paravertebral nerve block, intercostal block, transversus abdominis plane block, rectus sheath block, ilioinguinal block, iliohypogastric block
  • emergency surgery
  • fail epidural block after test dose of local anesthetics

结局指标

主要结局

Number of Patients Reporting Postoperative Verbal Rating Scale Pain at Rest More Than 7

时间窗: at postoperative 24 hours

Verbal Rating Scale Pain will routinely be assessed at postoperative 24 hours by the ward nurse. Minimum and maximum scores possible are 0 and 10. The higher values represent patients having more pain. Severe pain is defined as Verbal Rating Scale pain at rest more than 7.

次要结局

  • Number of Patients Requiring Rescue Analgesic Medication(during the period of retaining of epidural catheter up to 3 days after operation)
  • Duration Retaining Epidural Catheter(the period of retaining of epidural catheter up to 3 days after operation)
  • All Adverse Effects and Postoperative Complications.(the period of retaining of epidural catheter up to 3 days after operation)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mingkwan Wongyingsinn, MD

Assistant professor, Doctor

Siriraj Hospital

研究点 (1)

Loading locations...

相似试验