Satiation Attenuates BOLD Activity in Brain Regions Involved in Reward and Increases Activity in an Inhibitory Control Area: an fMRI Study in Healthy Volunteers.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Activation differences between satiated and pre-meal scan fMRI BOLD signal
研究概览
简要总结
To our knowledge no study has assessed the effects of a meal on neural responses to food cues and compared this with a condition simulating natural inter-meal hunger levels. This is important, as the existing literature often compares the effect of fasting to satiation, which may not reflect typical appetite processes. Thus, the purpose of this research was to examine the effect of a satiating lunch compared to a normal pre-meal state on blood oxygen level dependent (BOLD) activity in the human brain, as measured using functional magnetic resonance imaging (fMRI).
详细描述
We hypothesized that satiation would be associated with decreased brain activity across brain regions involved in both appetite and reward such as ventromedial prefrontal cortex, orbitofrontal cortex, ventral striatum, hypothalamus, insula, amygdala and hippocampus. 16 healthy participants (8 males) were scanned on two separate test days, before and after eating a meal to satiation, or after not eating for 4 hours (satiated vs. pre-meal). fMRI BOLD signals to the sight and/or taste of the stimuli were recorded. Participants were given questionnaires to complete about their mood state and appetite before and after all scans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Sufficiently fluent in English to understand the task and the instructions
排除标准
- •Currently taking medication
- •Past or current depression/dieting,
- •Food allergies
- •Pregnancy
- •BMI score outside the normal range
- •Any contraindications to fMRI scanning (e.g. pacemakers, mechanical heart valve, hip replacement, metal implants)
研究组 & 干预措施
Scanning
Repeated measures:
Satiation scan + Pre-meal scan
All participants undertook both scans
干预措施: Satiated / Pre-meal (Other)
Scanning
Repeated measures:
Satiation scan + Pre-meal scan
All participants undertook both scans
干预措施: MRI (Device)
结局指标
主要结局
Activation differences between satiated and pre-meal scan fMRI BOLD signal
时间窗: 6 months
次要结局
未报告次要终点