Investigation of the degree of concordance between changes in high frequency variable index and the timing of analgesic adjustments by anesthesiologists

Not Applicable

• Conditions: This is a secondary analysis of data from 48 cases from a previous study (UMIN000048816, study titile: Prediction of postoperative effectiveness of nerve block in video/ robotic -assisted thoracoscopic surgery by using high frequency variability index (HFVI), an index of parasympathetic tone: prospective observational study) ).

• Registration Number: JPRN-UMIN000052871
• Lead Sponsor: Fukushima Medical University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-11-22
• Last Update Posted: 22 January 2024
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Not provided

Exclusion Criteria

Patients or timings that fall into any of the following categories will be excluded from the study. 1. Timing before the start of surgery or after the end of surgery 2. Patients with a large number of intraoperative HFVI deficiencies 3. Patients for whom analgesic dosage adjustment was not performed during surgery 4. Timing of analgesic adjustment in advance of the upcoming stimulus as prior analgesia 5. Timing of periodic drug administration (e.g., periodic addition of fentanyl to adjust effective site concentration) 6. Timing of possible adjustment of analgesics for postoperative analgesia (e.g., addition of fentanyl at the end of surgery) 7. Timing of possible changes in HFVI levels due to bolus administration of circulatory agonists By excluding these cases or timings, the investigators identify when the anesthesiologist adjusted analgesics for adequate and/or inadequate analgesia. This task will be performed by three anesthesiologists out of the six principal investigators and research assistants, and the decision will be made with the approval of at least two of them.

Study & Design

• Study Type: Others,meta-analysis etc
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Percentage of significant changes in HFVI during the maintenance phase of anesthesia at the time of remifentanil dosage adjustment.

Secondary Outcome Measures

Name	Time	Method
During the anesthesia maintenance phase, evaluate the following four points. 1. Percentage of significant change in HFV at the time when fentanyl was administered. 2. Percentage of change in PSi value when analgesics (remifentanil and fentanyl) were adjusted. 3. Percentage of patients who actually received analgesics (remifentanil or fentanyl) at the time when it was considered appropriate to adjust the administration of analgesics based on the change in HFVI. 4. Percentage of patients who actually adjusted analgesics (remifentanil and fentanyl) when changes in PSi values were observed and changes in HFVI indicated that adjustments in analgesic dosing may be warranted.