Selenium effect in patients with atherosclerotic coronary artery disease
Phase 3
- Conditions
- Coronary artery disease.Atherosclerotic heart disease of native coronary artery with angina pectorisI25.11
- Registration Number
- IRCT20190724044322N1
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Willingness to participate in the study and sign informed consent form after full knowledge of the purpose and method of the study
Men and women aged 18-18 years old
Diagnosis of atherosclerosis by a physician with angiography with at least 50% vascular obstruction in at least one vessel
Not taking any antioxidant and anti-inflammatory supplements for at least 1 month before starting the study
Overweight and obesity (BMI = 25 - 35 Kg / m²)
Exclusion Criteria
Affecting by malignancies, autoimmune and infectious diseases
Blood disease
Osteoporosis
Chronic diseases such as liver, kidney and thyroid diseases
Pregnancy
Lactation
Consuming antacids
Consuming antibiotics
Consuming alcohol
Cigarette smoking
Allergies
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gene expression of IL-6. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR.;Gene expression of TNF-a. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR.;Gene expression of IL-1ß. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR.
- Secondary Outcome Measures
Name Time Method