A randomized prospective study on the effects of chronic administration of Melatonin on clinical manifestations, oxidative stress, inflammation, and sleep-wake rhythm in patients with Rheumatoid Arthritis

Faculdade de Medicina da Universidade Federal do Ceará0 个研究点开始时间: 2018年2月23日最近更新: 2023年5月29日

适应症

试验速览

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•Have a diagnosis of rheumatoid arthritis confirmed by a rheumatologist, according to international criteria; being with the disease activity stable and not having undergone a change of therapeutic regimen in the three months prior to inclusion; not have been hospitalized for eight weeks prior to inclusion; not to abuse alcohol or illicit drugs; be over 18 years of age, have no diagnosis of cardiac, hepatic or renal insufficiency, have signed the free and informed consent form. Pregnant or breastfeeding women were not included either.

•Patients without a conclusive diagnosis for rheumatoid arthritis; children under 18 years of age; unstable disease or in the process of therapeutic adequacy; hospital admission history in the eight weeks prior to inclusion; history of abusive use of alcohol or illicit drugs; refusal to participate in the study; pregnant or nursing women.

发起方

Faculdade de Medicina da Universidade Federal do Ceará