Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation

National and Kapodistrian University of Athens1 site in 1 country50 target enrollmentMarch 2011

ConditionsInfertility

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Infertility
Sponsor: National and Kapodistrian University of Athens
Enrollment: 50
Locations: 1
Primary Endpoint: number of oocytes (COCs)
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.

Registry

clinicaltrials.gov

Start Date

March 2011

End Date

September 2015

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

National and Kapodistrian University of Athens

Responsible Party

Principal Investigator

Siristatidis Charalampos, MD, PhD

Assistant Professor, Director of the ARU

National and Kapodistrian University of Athens

Eligibility Criteria

Inclusion Criteria

•poor responders (age\>40, previous POR, abnormal OR test)
•indication for IVF
•regular cycling patients
•BMI 19-35

Exclusion Criteria

•contraindication for clomiphene citrate use or to GnRH agonists antagonists
•BMI \> 35

Outcomes

Primary Outcomes

number of oocytes (COCs)

Time Frame: at oocyte recovery

Secondary Outcomes

Number/rate of participants whom the IVF cycle was cancelled(After the 1st week of ovarian stimulation, no oocytes at OR)
clinical pregnancy rate(6 weeks)
cancellation rate(from start of stimulation until ET)
live birth(more than 20 weeks)
miscarriage(pregnancy loss before 20 weeks of gestation, after a positive pregnancy test)
stimulation characteristics(from start of stimulation until embryo transfer)