Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- number of oocytes (COCs)
研究概览
简要总结
The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •poor responders (age>40, previous POR, abnormal OR test)
- •indication for IVF
- •regular cycling patients
- •BMI 19-35
排除标准
- •contraindication for clomiphene citrate use or to GnRH agonists antagonists
- •BMI > 35
研究组 & 干预措施
mild ovarian stimulation
100 mg CC by day 2 till 6, plus antagonist plus gonadotrophin 150-200IO until HCG triggering
干预措施: mild ovarian stimulation (Procedure)
conventional ovarian stimulation
300-450 IU of FSH starting by day 2 of menstrual cycle together with a fixed dose of GnRH antagonist starting by day 6 till egg recovery, or same doses using a GnRH agonist long protocol
干预措施: conventional ovarian stimulation (Procedure)
结局指标
主要结局
number of oocytes (COCs)
时间窗: at oocyte recovery
次要结局
- Number/rate of participants whom the IVF cycle was cancelled(After the 1st week of ovarian stimulation, no oocytes at OR)
- clinical pregnancy rate(6 weeks)
- cancellation rate(from start of stimulation until ET)
- live birth(more than 20 weeks)
- miscarriage(pregnancy loss before 20 weeks of gestation, after a positive pregnancy test)
- stimulation characteristics(from start of stimulation until embryo transfer)
研究者
Siristatidis Charalampos, MD, PhD
Assistant Professor, Director of the ARU
National and Kapodistrian University of Athens