Analysis of IVF Outcome After Minimal Stimulation vs. High Dose Stimulation for Patients With Low Ovarian Reserve
Overview
- Phase
- Not Applicable
- Intervention
- Letrozole, Gonadotropins
- Conditions
- Infertility
- Sponsor
- Sheba Medical Center
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Clinical pregnancy rates
- Last Updated
- 11 years ago
Overview
Brief Summary
The purpose of this study is to determine whether minimal ovarian stimulation for in vitro fertilization is superior to high dose stimulation. Number of mature eggs, number of embryos as well as pregnancy rates will be compared.
Detailed Description
A prospective randomized trial will be carried out. The Minimal stimulation (MS) protocol is based on low dose letrozole 2.5 mg over 5 days, starting from cycle day 2, overlapping with low dose gonadotropins, starting from day 3 of the letrozole at 150 units per day. GnRH antagonist wil be introduced to avoid premature LH surge when one or more of the growing follicles reached approximately 14 mm in size. The high dose stimulation protocol is based on high dose of gonadotropins (≥300 IU/day) throughout the cycle with the usage of gonadotropin-releasing hormone (GnRH) antagonist to avoid premature luteinizing hormone (LH) surge as described above.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of poor responder to ovarian stimulation
Exclusion Criteria
- •Patients undergoing pregestational diagnosis (PGD)
- •Patients using donor eggs
Arms & Interventions
Minimal stimulation protocol
Low dose Letrozole 2.5 mg over 5 days, starting from cycle day 2, overlapping with low dose gonadotropins, starting from day 3 of the Letrozole at 150 units per day. GnRH antagonist to avoid premature LH surge will be introduced when one or more of the growing follicles reached approximately 14 mm in size
Intervention: Letrozole, Gonadotropins
High dose protocol
High dose of gonadotropins (≥300 IU/day) starting from cycle day 3. GnRH antagonist will be introduced to avoid premature LH surge when one or more of the growing follicles will reach approximately 14 mm in size
Intervention: Gonadotropins
Outcomes
Primary Outcomes
Clinical pregnancy rates
Time Frame: 1 Year
Secondary Outcomes
- Number of High quality embryos(1 year)
- Number of eggs retrieved(1 year)