Clinical Translation of Curcumin Therapy to Treat Arterial Aging
试验速览
- 阶段
- 不适用
- 入组人数
- 118
- 试验地点
- 1
- 主要终点
- Nitric-oxide mediated endothelium-dependent dilation
研究概览
简要总结
The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •women must be postmenopausal
- •body mass index (BMI) <40 kg/m2
- •weight stable in the prior 3 months
- •absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG
排除标准
- 未提供
研究组 & 干预措施
Placebo pill
干预措施: Placebo pill (Drug)
Low-dose curcumin pill
干预措施: Low-dose curcumin pill (Drug)
High-dose curcumin pill
干预措施: High-dose curcumin pill (Drug)
结局指标
主要结局
Nitric-oxide mediated endothelium-dependent dilation
时间窗: 12 weeks
flow-mediated dilation and forearm blood flow responses to acetylcholine in the presence and absence of N'-monomethyl-L-arginine
Arterial Stiffness
时间窗: 12 weeks
Arterial pulse wave velocity
次要结局
- Endothelial cell oxidative stress and inflammation(12 weeks)
- Systemic oxidative stress and inflammation(12 weeks)