Oxytocin and placebo/nocebo effect

Completed

• Conditions: Placebo effect in healthy subjects

• Registration Number: NL-OMON25836
• Lead Sponsor: eiden University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

1.Healthy male volunteers between 18 and 35 years old;

2.Good understanding of written and spoken English.

Exclusion Criteria

1.Current psychiatric (DSM-IV) conditions;

2.All conditions that might interfere with the participant's safety and/or the study protocol: e.g., severe somatic or psychological morbidity (e.g., heart and lung diseases, low blood pressure, family history of an acute heart failure or a death due to an acute heart failure, DSM-IV psychiatric disorders, and current use of analgesics drugs)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To investigate whether exogenous oxytocin administration enhances the placebo effect, the oxytocin and control groups will be compared on the difference between subjective pain ratings between the yellow (control) and green (placebo) cues in the heat pain conditioning task in the first part of the testing phase.

Secondary Outcome Measures

Name	Time	Method
To investigate the effects of exogenous oxytocin administration on nocebo effect, the oxytocin and control groups will be compared on the difference between subjective pain ratings between the red (nocebo) and yellow (control) cues in the heat pain conditioning task in the first part of the testing phase.