The role of oxytocin on placebo/nocebo effects in a pain conditioning paradigm.
Completed
- Conditions
- Het onderzoek wordt bij gezonde personen uitgevoerd. Het onderzoek kan voor nieuwe inzichten zorgen bij therapeutische interventies voor pijn.not applicable
- Registration Number
- NL-OMON45392
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
- Men between 18 and 35 years old
- Good understanding of written and spoken English
Exclusion Criteria
- Refusal to give written informed consent
- Conditions that might interfere with the participant's safety and/or the study protocol: severe somatic or psychological morbidity (e.g., heart and lung diseases, or DSM-IV psychiatric disorders)
- Family history of an acute heart failure or death caused by an acute heart failure
- Chronic or acute pain complaints
- Current use of analgesics
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is a difference between the oxytocin and placebo<br /><br>groups in the placebo effect. The placebo effect will be calculated as the<br /><br>difference in the subjective pain ratings between the yellow (control) and<br /><br>green (placebo) cues in the heat pain conditioning task in the testing phase. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameter is the difference between the groups in the<br /><br>nocebo effect. The nocebo effect will be calculated as a difference in the<br /><br>subjective pain ratings between the red (nocebo) and yellow (control) cues in<br /><br>the heat pain conditioning task in the testing phase.</p><br>