Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion

Not yet recruiting

• Conditions: Abnormal Uteroplacental Circulation
• Interventions: Other: Doppler ultrasound measurement of changes in uterine artery blood flow

• Registration Number: NCT06043804
• Lead Sponsor: Second Affiliated Hospital of Wenzhou Medical University

Brief Summary

Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion.

Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-09
• Study First Submitted: 2023-09-05
• Study First Submitted QC: 2023-09-12
• Last Update Submitted: 2023-09-12
• Study First Posted: 2023-09-21
• Last Update Posted: 2023-09-21
• Study Start: 2023-10-01
• Primary Completion: 2025-12-31
• Study Completion: 2026-04-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
2. Complete maternal clinical data;

Exclusion Criteria

1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
2. multiple pregnancy;
3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
4. Patients who have chronic diseases or are receiving chronic treatment.

Pregnant women with recurrent pregnancy loss Group

Inclusion Criteria:

1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
2. Complete maternal clinical data;
3. There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times;

Exclusion Criteria:

1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
2. multiple pregnancy;
3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
4. Patients who have chronic diseases or are receiving chronic treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pregnant women with recurrent pregnancy loss	Doppler ultrasound measurement of changes in uterine artery blood flow	Spontaneous abortion of three or more consecutive sexual partners
healthy pregnant woman	Doppler ultrasound measurement of changes in uterine artery blood flow	healthy pregnant woman

Primary Outcome Measures

Name	Time	Method
Pulsatility index	it can be monitored for up to 12 weeks	Pulsatility index of the left and right main uterine arteries
Resistive index	it can be monitored for up to 12 weeks	Resistive index of the left and right main uterine arteries
Systolic-to-diastolic ratio	it can be monitored for up to 12 weeks	Systolic-to-diastolic ratio of the left and right main uterine arteries