Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 主要终点
- Pulsatility index
研究概览
简要总结
Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion.
Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 40 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
- •Complete maternal clinical data;
排除标准
- •The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
- •multiple pregnancy;
- •Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
- •Patients who have chronic diseases or are receiving chronic treatment.
- •Pregnant women with recurrent pregnancy loss Group
- •Inclusion Criteria:
- •Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks;
- •Complete maternal clinical data;
- •There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times;
- •Exclusion Criteria:
- •The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography;
- •multiple pregnancy;
- •Patients with congenital uterine malformations, uterine fibroids and any other uterine disease;
- •Patients who have chronic diseases or are receiving chronic treatment.
结局指标
主要结局
Pulsatility index
时间窗: it can be monitored for up to 12 weeks
Pulsatility index of the left and right main uterine arteries
Resistive index
时间窗: it can be monitored for up to 12 weeks
Resistive index of the left and right main uterine arteries
Systolic-to-diastolic ratio
时间窗: it can be monitored for up to 12 weeks
Systolic-to-diastolic ratio of the left and right main uterine arteries
次要结局
未报告次要终点