Diagnostic Value of Doppler Ultrasound for Early Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Aristotle University Of Thessaloniki
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- RI as a prognostic factor for AKI persistence
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent Acute Kidney Injury (AKI) using the color Doppler Ultrasound derived Renal Resistive Index (RI) and semi-quantitative evaluation of intra-renal vascularization in septic patients in an Intensive Care Unit (ICU).
Methods: Prospective observational cohort study with unselected, with 32 adult consecutive septic patients. Patients were divided into 3 groups: Group 1: patients without progression to AKI, Group 2: transient AKI, Group 3: persistent AKI.
Detailed Description
Purpose: The aim of this study was to assess the ability of early discrimination between transient and persistent AKI using the color Doppler Ultrasound derived Renal Resistive Index (RI) and semi-quantitative evaluation of intra-renal vascularization in septic patients in an Intensive Care Unit (ICU). Additionally, the investigators aimed to identify whether these indexes are early predictors of the prognosis of renal function in this group of patients. And compare the diagnostic accuracy of those and other renal indexes for the identification of AKI reversibility. Methods: This was a prospective observational cohort study with unselected, consecutive septic patients included. Thirty-two adult septic patients hospitalized in a general ICU were studied. After the determination of sepsis, patients were divided into 3 groups: Group 1 included patients without progression to AKI, Group 2 included patients with transient AKI and Group 3 patients with persistent AKI.
Investigators
Evangelos Kaimakamis
Principal Investigator
Aristotle University Of Thessaloniki
Eligibility Criteria
Inclusion Criteria
- •Septic patients in ICU
- •Age 18 years or older
Exclusion Criteria
- •ICU stay less than 3 days
Outcomes
Primary Outcomes
RI as a prognostic factor for AKI persistence
Time Frame: 3 days
without units (range 0 to 1)
Secondary Outcomes
- semi-quantitative US evaluation of renal vasculature(3 days)
- FENa (Fractional Excretion of Sodium)(3 days)