Comparison of the Hemodynamic Changes in Patients Under Treatment With Bisoprolol Versus Atenolol
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- central blood pressure
Study Overview
Brief Summary
At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness.
This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 21 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Hypertension
- •Metabolic syndrome
Exclusion Criteria
- •Severe hypertension >180/110
- •Secondary hypertension
- •Contraindication for betablockers
- •Prior treatment with betablockers (up to one month before inclusion)
- •History of neoplastic disease
- •Patients that do not sign informed consent
Arms & Interventions
Atenolol-Bisoprolol
Intervention: Atenolol (Drug)
Atenolol-Bisoprolol
Intervention: Bisoprolol (Drug)
Outcomes
Primary Outcomes
central blood pressure
Time Frame: two months
Secondary Outcomes
- cardiac index(two months)
- pulse wave velocity(two months)
- peripheral resistance(two months)
Investigators
Lucas Aparicio
MD
Hospital Italiano de Buenos Aires