Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol

Phase 4

Completed

• Conditions: Metabolic Syndrome; Hypertension
• Interventions: Drug: Atenolol; Drug: Bisoprolol

• Registration Number: NCT01939509
• Lead Sponsor: Hospital Italiano de Buenos Aires

Brief Summary

At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness.

This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2012-02-01
• Study First Submitted QC: 2013-09-10
• Study First Posted: 2013-09-11
• Primary Completion: 2014-10
• Study Completion: 2014-11
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-04
• Last Update Posted: 2014-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Hypertension
• Metabolic syndrome

Exclusion Criteria

• Severe hypertension >180/110
• Secondary hypertension
• Contraindication for betablockers
• Prior treatment with betablockers (up to one month before inclusion)
• History of neoplastic disease
• Patients that do not sign informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Atenolol-Bisoprolol	Bisoprolol	-
Atenolol-Bisoprolol	Atenolol	-

Primary Outcome Measures

Name	Time	Method
central blood pressure	two months

Secondary Outcome Measures

Name	Time	Method
cardiac index	two months
pulse wave velocity	two months
peripheral resistance	two months

Trial Locations

Locations (1)

Hospital Italiano de Buenos Aires; 🇦🇷 Buenos Aires, Argentina