Clinical study on Psychopharmacological therapeutic efficacy of Vidarikand (Pueraria tuberosa Roxb. ex Willd) in the Management of Chittodwega (Generalized Anxiety Disorder) - An Open Randomized Controlled Clinical trial

Chittodwega is a psychological disorder which can be defined as an ’anxious state of mind.’ Generalized Anxiety disorder’ is an anxiety disorder characterized by anxiety and worry that is not associated with a particular object, situation or event but seems to be a constant feature of a person’s day to day life, along with physical

symptoms of stress lasting a period of 6 months.

Impact of GAD on quality of life : Excessive concern, restlessness, difficulty sleeping, tiredness, irritability, sweating, trembling etc. interfere with work, relationships and other parts of life, suicidal thoughts, if untreated may lead to major psychological disorders (psychosis, schizophrenia)

GAD is under detected due to fear and shyness. It has high prevalence rates, poor quality of life, difficulties in detection, treatment, tendency to be chronic and associated with comorbidities. Even then it remains least studied.

Treatment gap : 70-80 %

Problems in conventional treatments : SSRIs have various side effects ( Nausea, Drowsiness, Insomnia, habit forming, sedating, sexual problems, agitation etc.)

Need for safer treatment : All these limitations are encouraging the patients to explore for possible therapies in complementary and alternative systems of medicine. Ayurveda is a great treasure of precious concepts like Rasayana (Rejuvenation therapy) which can be very well utilized to combat with this burning issue.

In Sushrut Apasmar Chikitsa, use of Vidaryadi gana and Kakolyadi gana have been mentioned which is a direct reference for use of Vidarikand (Su.Uttarsthana.61.29) for our present study of Manas vikar. Besides, Puerarin an active constituent of vidari has already been proven as an anxiolytic, neurotonic. With present study we hope to explore the role of Vidarikand in Chittodwega.