Comparison of local versus systemic tranexamic acid in total knee replacement
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Primary Osteoarthritis Knee
- Registration Number
- CTRI/2017/07/009076
- Lead Sponsor
- SUNSHINE HOSPITALS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 113
Inclusion Criteria
1. All patients undergoing total knee arthroplasty for primary
arthroplasty knee
2.Patients who are willing to participate in the study.
3.Patient without exclusion criteria.
Exclusion Criteria
1.Allergy to the TXA
2.H/O Coagulopathy,abnormal PT or APTT
3.Past H/O Thromboembolic event
4.Treatment with Aspirin or NSAIDS in the last week
5.plasma creatinine > 115 micro moles /litre for males
And >100 micro moles/litre in females.
6.Acute infection[eg;leukocytosis or fever]
7.Malignancy
8.MI in preceding 12 months,unstable angina
9.Patient who were given plasma in perioperative period
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative Hemoglobin dropTimepoint: Assessed at 3 days of surgery
- Secondary Outcome Measures
Name Time Method Perioperative blood loss, need for post operative <br/ ><br>blood transfusion, impairment of renal function, <br/ ><br>occurrence of deep vein thrombosisTimepoint: 6 weeks