Muscle-Atrophy, Physical Performance, and RelatedAlterations in Metabolic Milieu, Inflammaging andBiological Age in ISS Crew Members
- Conditions
- Muscle wasting
- Registration Number
- DRKS00025369
- Lead Sponsor
- Institut für Luft- und Raumfahrtmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 16
Astronaut group:
- Astronauts with a planned mission with a minimum of 5 months and a maximum of one year.
Master Athlete group:
- Regular training (>4 hrs per week) and participation in master athletics events.
- Age (+/- 2 years) and sex matched to one participant of the astronauts
- Body mass index = 28 kg/m²
Non-physically active group:
- Physical activity limited to 20 kilocalories per kg/Bodyweight per week
- Age (+/- 2 years) and sex matched to one participant of the astronauts
- Body mass index =28 kg/m²
All groups:
- Ability to perform VO2max testing, as defined by local med-ops
- Ability to consent
- Agreement and signed informed consent before the study
•Severe injuries or abnormalities of the lower extremity that interfere with muscle strength testing or vertical jump testing
•Any debilitating disease, such as cancer or severe auto-immune diseases (use of anti-inflammatory drugs, statins therapy) that are likely to affect the inflammatory / anti-inflammatory balance
•Any chronic infectious disease (hepatitis, HIV) that is likely to affect the inflammatory / anti-inflammatory balance
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method