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临床试验/NCT00204945
NCT00204945已完成不适用

Acute Responses in Diastolic Heart Failure

University of Wisconsin, Madison2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2005年2月最近更新:
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适应症
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
15
试验地点
2
主要终点
arterial tonometry
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

  1. Research question: What is the response of the heart's pumping function to changes in heart chamber pressures?
  2. Experimental design: Patients undergoing routine cardiac catheterization will be studied. A thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery. After several minutes of quiet rest, baseline hemodynamics will be obtained, including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta. In addition, a brief echocardiogram will be performed, to determine ejection fraction and indices of diastolic filling. Finally, arterial tonometry will be obtained in quick succession from the brachial, radial, femoral, and carotid arteries. Following the collection of baseline data, a bolus and infusion of nesiritide will be started. After 10 minutes of nesiritide infusion, with the drug still infusing, a full set of invasive hemodynamics will again be obtained, as well as brief echocardiographic and arterial tonometry examinations.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Single Group
主要目的
Health Services Research
盲法
None

入排标准

年龄范围
18 Years 至 90 Years（Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •Cardiac catheterization

排除标准

  • •Unstable coronary syndrome,
  • •Critical coronary stenoses (>90%),
  • •Severe peripheral vascular disease,
  • •Symptomatic hypotension at completion of routine diagnostic cath,
  • •Significant valvular disease, resting heart rate >120 beats/min,
  • •Ejection fraction <45%,
  • •Presence of contraindications to nesiritide administration,
  • •Any evidence of clinical instability.

结局指标

主要结局

arterial tonometry

时间窗: following catheterization, then following 10 minutes of nesiritide infusion

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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