Changes in Microvascular perfusion, Exercise Tolerance and Perioperative Hemostasis after Treatment with Intravenous Iron of Patients with Mild Anemia Undergoing Arterial Vascular Surgery

Completed

• Conditions: 10002086; Vascular disease; vascular surgery; 10003184

• Registration Number: NL-OMON38492
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Adult subjects (age 18-85 years)
Elective vascular surgery
Type of anemia that can be treated by iron injections
Preoperative hemoglobin levels of 13 - 10 g/dL or 8.1 - 6.2 mmol/L in males and 12 - 10 g/dL or 7.5 - 6.2 mmol/L in females.
Informed consent

Exclusion Criteria

Re-operation
Emergency operation
Pregnancy
Patients that are scheduled to receive any form of anemia treatment
Patients with a contraindication for receiving iron
Patients with COPD or asthma
Patients with severe renal failure or renal replacement therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in exercise tolerance (submaximale bicycle test)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Microvascular perfusion (intravital microscopic imaging of the sublingual<br /><br>microvasculature)<br /><br>Perioperative hemostasis (blood samples)</p><br>