Reduced Microvascular Blood Volume as a Driver of Coronary Microvascular Disease in Patients with Non-Obstructive Coronary Artery Disease: The MICORDIS-study
Recruiting
- Conditions
- on-obstructive coronary artery diseaseCoronary microvascular dysfunctionCapillary recruitmentCapillary rarefaction
- Registration Number
- NL-OMON23861
- Lead Sponsor
- Amsterdam UMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 56
Inclusion Criteria
Patient group:
- Age > 40 years
Exclusion Criteria
- age > 80 years
- Obstructive coronary artery disease, defined as 50% or more obstruction of any coronary artery
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint is the difference in myocardial blood volume (MBV) between non-obstructive coronary artery disease patients and healthy controls. We compare MBV between groups at baseline, during hyperinsulinemia and during increased cardiac contraction.<br>MBV is measured using myocardial contrast echocardiography. Hyperinsulinemia is induced by a two hour hyperinsulinemic euglymic-clamp and cardiac contraction is increased via the infusion of dobutamine.
- Secondary Outcome Measures
Name Time Method 1. MBV, MBF, ÄMBV, baseline characteristics, cardiovascular risk factors, questionnaire results, blood parameters and measurement indexes compared between males and females from the patient and control group.<br /><br>2. Differences in MBV between baseline and after HE-clamp of the patient and control group. Differences in MBV between baseline and after dobutamine stress of the patient and control group.<br /><br>3. Baseline characteristics, cardiovascular risk factors, questionnaire results and measurement indexes compared between the patient and control group.<br /><br>4. MBV, MBF and ÄMBV compared between insulin resistant subjects and non-insulin resistant subjects.<br /><br>5. Correlation between MBV measured with MCE and MBV measured with CMR.<br /><br>6. Protein expression and phosphorylation of microvascular endothelial cells compared between the patient and control group.