Disturbances in microvascular perfused boundary region and plasma levels of syndecan-1 and heparan sulfate in cardiopulmonary resuscitated patients during re-warming phase of therapeutic hypothermia treatment.

Completed

Conditions: Cardiac arrest
10019280

Registration Number: NL-OMON38597

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 39

Inclusion Criteria

* age *18 years
* out-of hospital cardiac arrest with spontaneous return of circulation
* undergoing mild therapeutic hypothermia
* admittance to the intensive care unit
* written informed/deferred consent

Exclusion Criteria

* severe traumatic brain injury
* cardiac arrest due to submersion
* infection already present before collapse
* moribund patients

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Determine whether and to what extent changes in microvascular PBR, as measure<br /><br>for glycocalyx damage, occur in survivors and non-survivors of CA during the<br /><br>re-warming phase of therapeutic hypothermia treatment.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Determine whether and to what extent changes in syndecan-1 and heparan<br /><br>sulfate plasma levels, as measure for glycocalyx damage, occur in survivors and<br /><br>non-survivors of CA during the re-warming phase of therapeutic hypothermia<br /><br>treatment.<br /><br>- Determine the association of syndecan-1 and heparan sulfate plasma levels<br /><br>with the PBR in post-CA patients during the re-warming phase of therapeutic<br /><br>hypothermia treatment.<br /><br>- Determine whether and to what extent changes in microcirculatory perfused<br /><br>vessel density (PVD) and mean flow index (MFI) occur in survivors and<br /><br>non-survivors of CA during the re-warming phase of therapeutic hypothermia<br /><br>treatment.</p><br>