Comparative evaluation of Natural vs Synthetic MMP inhibitors on MMP-2 and MMP-9 in patients with pulpal necrosis and apical periodontitis – A Randomized controlled trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Measure the level of MMP-2 and MMP-9 in Calcium hydroxide with 2% Chlorhexidine and Epigallocatechin gallate groups in patients with pulpal necrosis and apical periodontitis.
研究概览
简要总结
·To evaluate levels of mmp-2 in patients with pulpal necrosis and apical periodontitis using Calcium Hydroxide with 2% Chlorhexidine as intracanal medicament using sandwich ELISA
·To evaluate levels of mmp-2 in patients with pulpal necrosis and apical periodontitis using Epigallocatechin gallate as intracanal medicament using sandwich ELISA
·To evaluate levels of mmp-9 in patients with pulpal necrosis and apical periodontitis using Calcium Hydroxide with 2% Chlorhexidine as intracanal medicament using sandwich ELISA
•
·To evaluate levels of mmp-9 in patients with pulpal necrosis and apical periodontitis using Epigallocatechin gallate as intracanal medicament using sandwich ELISA
·To compare levels of mmp-2 in patients with pulpal necrosis and apical periodontitis treated using Calcium Hydroxide with 2% Chlorhexidine and in patients with pulpal necrosis and apical periodontitis treated using epigallocatechin gallate using sandwich ELISA
·To compare levels of mmp-9 in patients with pulpal necrosis and apical periodontitis treated using Calcium Hydroxide with 2% Chlorhexidine and in patients with pulpal necrosis and apical periodontitis treated using epigallocatechin gallate using sandwich ELISA
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Mandibular premolar and canine teeth diagnosed with pulp necrosis and apical periodontitis 2 Teeth with mature apices 3 Patients with age between 18.
排除标准
- •1 Teeth with calcified canals and aberrant root canal morphology.
- •2 Pregnant or lactating patients 3 Patients with history of allergy to any of the components of local anaesthesia 4 Teeth with previous RCT 5 Severely damaged or mutilated teeth 6 Patient with systemic disease 7 Patient with periodontal disease.
结局指标
主要结局
Measure the level of MMP-2 and MMP-9 in Calcium hydroxide with 2% Chlorhexidine and Epigallocatechin gallate groups in patients with pulpal necrosis and apical periodontitis.
时间窗: Before placement of Intracanal medicament and after 7 days of placement of Intracanal medicament.
次要结局
- To compare levels of MMP-2 & MMP-9 in patients with pulpal necrosis & apical periodontitis treated using(Calcium Hydroxide with 2% Chlorhexidine & in patients with pulpal necrosis & apical periodontitis treated using epigallocatechin gallate using sandwich ELISA)
研究者
Palak Jain
Manav Rachna Dental College