Efficacy and Safety of Antiplatelet Therapy After Endovascular Aortic Repair

Completed

• Conditions: Abdominal Aortic Aneurysms (AAA); Endovascular Aneurysm Repair (EVAR)

• Registration Number: NCT06876727
• Lead Sponsor: Samsung Medical Center

Brief Summary

This study was a target trial emulation using the National Health Claims database established by the Korean National Health Insurance Service (K-NHIS). 8,325 patients were included.

Detailed Description

Among these patients, any patients who were prescribed SAPT or DAPT at the date of discharge from the index hospitalization for standard EVAR were defined as being in the SAPT group (N=4,162) and the DAPT group (N=4,163), respectively.

Study Timeline

• Study Start: 2003-01-01
• Primary Completion: 2023-09-30
• Study Completion: 2023-09-30
• Status Verified: 2025-03
• Study First Submitted: 2025-03-10
• Study First Submitted QC: 2025-03-10
• Last Update Submitted: 2025-03-10
• Study First Posted: 2025-03-14
• Last Update Posted: 2025-03-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8325

Inclusion Criteria

• All patients who underwent EVAR for AAA and were successfully discharged

Exclusion Criteria

• Patients who had experienced a myocardial infarction
• Patients who had experienced a stroke
• Patients who had experienced percutaneous coronary intervention
• Patients who had history of peripheral disease
• Patients who had major bleeding event within 1 year of admission
• Those prescribed non-vitamin K antagonist oral anticoagulant or warfarin
• Patients who did not prescribe any antiplatelet therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Major adverse cardiac and cerebrovascular events (MACCE)	1 year after EVAR	composite of all-cause death, myocardial infarction (MI), or ischemic stroke
Major or clinically relevant non-major bleeding	1 year after EVAR	Diagnostic codes in the primary or secondary position and transfusion receipt
Re-intervention or surgery for AAAs	1 year after EVAR	Re-intervention or surgery for AAAs